3D Cell Culture Market Size, Share & Trends Report

3D Cell Culture Market Size, Share & Trends Analysis Report By Technology, By End Use, By Application (Tissue Engineering, Drug Development, Stem Cell Research, Cancer), By Culture Component, And Segment Forecasts 2018 - 2024

  • Published Date: Jun, 2018
  • Base Year for Estimate: 2016
  • Report ID: GVR-1-68038-091-0
  • Format: Electronic (PDF)
  • Historical Data: 2013 - 2015
  • Number of Pages: 153

Industry Insights

The global 3D cell culture market size was valued at USD 558.0 million in 2016, exhibiting a 14.8% CAGR during the forecast period. Introduction of novel scaffolds and matrices, coupled with ongoing advancements in research and analytical processes, is expected to fuel growth.

U.S. 3D cell culture market

Three-dimensional cellular models are derived using a variety of structural hydrogels and scaffolds, which in turn, aid in boosting revenue generation. However, researchers often encounter troubles while cultivating 3D cellular models using scaffolds as they impede cell-to-cell interactions and interfere in assembly of extracellular matrices. These drawbacks are resulting in the need for technological advancements in scaffold-free technology.

Emergence of scaffold-free technology as a promising platform for development of translational pathway for tissues is anticipated to propel the uptake of cellular three-dimensional culture techniques. Moreover, advent of 3D bioprinting, which facilitates fabrication of scaffold-free tissue units through fusion of tissue spheroids, enables development of functional tissue-engineered constructs with distinct 3D structures. Such developments are anticipated to drive market growth.

Growth in 3D cell culture techniques is being driven by rising global R&D investments in cell-based research. In addition, presence of organizations such as International Society for Stem Cell Research is influencing funding support and fostering scientific growth. This is anticipated to raise demand for cellular three-dimensional culture techniques in the near future.

Technology insights

Mammalian cellular cultures have been extensively used for cellular biology and molecular research in order to understand human physiology and the underlying mechanism behind chronic diseases. Low success rates of two-dimensional cellular culture-based assays in determination of therapeutic efficacy pronounces the need for advancement in cellular culture technology.

Demand for scaffold-free 3D cell culture products is increasing owing to challenges faced in use of scaffolds. These challenges include interference of scaffolds with cell-to-cellular interactions and in assembly of cell produced Extra Cellular Matrices (ECM).

Implementation of bioreactor-based 3D culture systems in conjunction with innovative sensor technologies has proved to be a key technology for gaining insights into cellular physiology and complexity of organ development. A wide range of products based on 3D bioreactors is offered by companies such as Sigma Aldrich Corporation, Biotek, Biogenuix, and Hypoxygen.

Application Insights

A cellular level real-time study of mammalian physiology is facilitated by the ability of 3D cell culture technique to manipulate genetic factors. Three-dimensional culture systems play a critical role in investigating the cross-linkage between various intercellular pathways in tumor formation. This is attributive to the ability of 3D culture systems to mimic tumor cells’ in vivo environment.

3D bioprinting enables creation of 3D printed building blocks of ESCs, which could be further used for micro-organ generation and tissue regeneration experiments. Such models are rapidly being adopted for organ generation using iPSCs and hESCs in stem cell-based research. Furthermore, implementation of cellular models for differentiation and expansion of pluripotent stem cells based on principle of scaffolding contributes to lucrative growth of stem cell research applications.

End-use Insights

Biotech and pharma companies, research laboratories, hospitals and diagnostic centers, and academic institutes are major entities that use in-vitro cellular culture products. Biotech and pharma companies dominated the 3D cell culture market with over 47.0% revenue share in 2016 owing to rapid adoption of these systems for drug discovery, toxicity screening, and development of regenerative medicine. Efficient screening and target validation provided by these systems resulted in higher implementation in drug discovery.

Brazil 3D cell culture market

Lucrative growth is projected for research laboratories as well as hospitals and diagnostic centers. Availability of funding for research projects conducted by academic and research institutes is expected to drive revenue growth.

Culture Component Insights

Key components include media, reagents, and consumables. High-quality media is required to maintain cellular lines, especially in stem cell culture. Even slight differences in media have a large impact on cells due to a number of reasons. In addition, media requirements, in terms of volume, is higher than other components. The aforementioned reasons collectively contribute to the largest revenue share of media components.

Specific reagents form an essential component for in-vitro cellular growth. Absence of such components leads to failure in cell proliferation. Serum supplements are available in different varieties such as caprine (goat), human, porcine (pig), ovine (sheep), rabbit, equine (horse), chicken, and bovine (cow). Importance of sera and other supplements in organoid regeneration and high cost of essential reagents is projected to drive the reagents and consumables segments.

Regional Insights

North America dominated the market with a share of over 41.0% in 2016.Chronic diseases account for majority of the healthcare expenditure incurred in U.S. and Canada. This contributes to rapid development of three-dimensional cellular culture products by major players for cell-based therapeutics. In addition, presence of several pharma and biotech organizations implementing the technology in collaboration with research laboratories drives this regional market.

Asia Pacific is expected to witness the fastest growth over the forecast period due to developing infrastructure in this region, coupled with increasing awareness about upcoming technologies in healthcare amongst the population. Asia Pacific harbors 60.0% of the world population; thus even a lower prevalence of chronic diseases translates into a large number of infected people, which is the leading factor driving segment growth. Furthermore, unmet needs of patients and untapped areas in this region have been attracting international market players and this is expected to boost revenue generation through to 2024.

3D Cell Culture Market Share Insights

Key players operating in this vertical are Merck, 3D Biotek LLC; 3D Biomatrix; Nano3D Biosciences Corning Inc.; VWR International, LLC; Thermo Fisher Scientific; Global Cell Solutions, Inc.; Becton Dickinson and Company; Tecan; InSphero AG; and Lonza Group.

These companies are focusing on collaborations with laboratories for commercialization of technologies that are not yet established in the market space. For instance, in March 2014, Corning, Inc. extended its collaboration with ATCC for cell culture research. Through this move, the company will co-develop new applications for existing Corning and ATCC cellular biology products.

Report Scope

Attribute

Details

Base year for estimation

2016

Actual estimates/Historical data

2013 - 2015

Forecast period

2016 - 2024

Market representation

Revenue in USD Million and CAGR from 2017 to 2024

Regional scope

North America, Europe, Asia Pacific, Latin America, Middle East & Africa

Country scope

U.S., Canada, Germany, U.K., Japan, China, Brazil, South Africa

Report coverage

Revenue forecast, company share, competitive landscape, growth factors and trends

15% free customization scope (equivalent to 5 analyst working days)

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Segments Covered in the Report

This report forecasts revenue growth at global, regional, and country levels and provides an analysis on latest industry trends in each of the sub-segments from 2013 to 2024. For the purpose of this study, Grand View Research has segmented the global 3D cell culture market report on the basis of technology, application, end use, culture component, and region:

  • Technology Outlook (Revenue, USD Million, 2013 - 2024)

    • Scaffold based

      • Hydrogels

      • Polymeric scaffolds

      • Micropatterned Surface Microplates

    • Scaffold free

      • Hanging drop microplates

      • Spheroid microplates containing Ultra-Low Attachment (ULA) coating

      • Microfluidic 3D cell culture

      • Magnetic levitations & 3D bioprinting

    • 3D Bioreactors

  • Application Outlook (Revenue, USD Million, 2013 - 2024)

    • Cancer

    • Tissue engineering & Immunohistochemistry

    • Drug development

    • Stem cell research

    • Others

  • End-use Outlook (Revenue, USD Million, 2013 - 2024)

    • Biotechnology and pharmaceutical industries

    • Research laboratories and institutes

    • Hospitals and diagnostic centers

    • Others

  • Culture Component Outlook (Revenue, USD Million, 2013 - 2024)

    • Media

    • Reagents and Consumables

  • Regional Outlook (Revenue, USD Million, 2013 - 2024)

    • North America

      • U.S.

      • Canada

    • Europe

      • Germany

      • U.K.

    • Asia Pacific

      • Japan

      • China

    • Latin America

      • Brazil

    • Middle East & Africa

      • South Africa

Key questions answered by the report
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