Large & Small-Scale Bioprocessing (Biopharmaceutical Manufacturing) Market Report

Large & Small-Scale Bioprocessing (Biopharmaceutical Manufacturing) Market Analysis By Workflow (Downstream, Upstream, Fermentation), By Product, By Use-type (Multi-use, Single-use), By Mode (In-house, Outsourced), And Segment Forecasts, 2018 - 2025

  • Published Date: Dec, 2017
  • Base Year for Estimate: 2016
  • Report ID: GVR-2-68038-277-8
  • Format: Electronic (PDF)
  • Historical Data: 2014 - 2016
  • Number of Pages: 150

Industry Insights

The global large & small-scale bioprocessing (biopharmaceutical manufacturing) market size was estimated at USD 26.12 billion in 2016. Bioprocess engineering has been effectively explored for the development of biopharmaceuticals and it has provided bio manufacturers and contract manufacturing organizations (CMO) with lucrative avenues of growth. This, in turn, is expected to attract focused efforts to bolster the market adoption of various bioprocess engineering solutions.

Biopharmaceuticals manufacturing is expected to serve as the lucrative source of revenue within the pharmaceutical industry in the coming years. Hence, with gradual shift of pharmaceutical industry towards biopharmaceuticals, bioprocessing market is also expected to grow at significant pace throughout the forecast period.

China large & small-scale bioprocessing (biopharmaceutical manufacturing) market

Rapid advancements in bioprocess engineering, including the evolution of contract services and single-use technology, have contributed huge success to the biopharmaceutical manufacturing industry. Emerging innovations, such as nano-biocatalysts, aimed to improve the turnaround times by enhancing enzyme activity and stability enhance the bioproduction, thus driving revenue generation. 

Previously, only a handful of firms were able to handle the entire value chain of large-molecule bioproduction. However, in the current scenario, there are many companies in the space that are involved in the development of biologics and biosimilars owing to the technological advances in bioprocessing technology.

Driven by high demand for biopharmaceuticals, suppliers' product portfolio for biomanufacturing has become more robust. Suppliers of bioreactors and other ancillary bioprocessing equipment are undertaking endeavors to fulfill growing expectations of bio manufacturers with respect to cost, space requirement, and portability.

Budgets for biomanufacturing operations are expanding in essentially all aspects. Companies are observed making significant investments in biomanufacturing-related R&D. This also includes hiring expert professionals and expansion of manufacturing capacity. These factors are expected to play a pivotal role in reshaping the bioprocessing of various products in the near future.

Moreover, introduction of high throughput process development and data analysis services enables entities to gain insight into the production process for product development and consequently optimizes the whole process. Evolution of bioremediation as a promising solution for cost-effective treatment of contaminants like heavy metals has also contributed to the enhanced adoption of bioprocessing equipment.

However, even though this market is expected to witness significant growth in the coming years, purification and stability issues regarding protein production as well as environmental concerns pertaining to the use of single-use bioprocessing equipment are expected to hamper the growth of the market to a certain extent.

Workflow Insights

The bioprocessing workflow comprises three stages viz., upstream processing, fermentation, and downstream processing on the basis of activities carried out for conversion of crude raw material to final finished product.

Product purification which is the key step in downstream processing is considered as the most challenging & crucial step and thus, demands more attention. This factor has contributed to the large share of this segment in 2016.

Moreover, any advancement in bioprocessing engineering directly affects the production yield, which in turn, positions the downstream processing segment as the center of significant attraction of a number of major big pharma stakeholders.

However, with advent of single-use technology coupled with growth in mammalian titer for production, upstream processing is expected to grow at lucrative pace throughout the forecast period. In addition, technological modifications in bioreactors and fermenters are projected to accelerate revenue growth for fermentation segment in the coming years.

Product Insights

Bioreactors accounted for a substantial share of the revenue inflow owing to the high usage rate coupled with large-scale bioproduction requirements from key industry participants. Automated cell culturing using specialized bioreactor designs holds great significance for the development of value-added products, thereby influencing growth in this segment.

Availability of a wide range of bioreactors on the basis of operation mode, phase type, capacity, fluid flow type, use type, and applications is expected to boost revenue generation in this segment in the near future. Other products offered in this market include bags & containers, filtration assemblies, cell culture products, and bioreactors accessories.

Cell culture product is the fastest growing segment. This is mainly attributed to the ongoing advancements in cell line development including development of recombinant cell line. Production of biopharmaceutical derived cell lines from mammalian cell lines is supportive for the projected growth of this segment.

Application Insights

Production of biopharmaceuticals & biotherapeutics captured the largest share owing to the commercial success of biologics & biosimilars for clinical use in the current scenario. Pharmacists are leveraging the wide spectrum application of bioprocess engineering to develop organism derived therapeutics, which in turn are expected to drive the growth of this segment.

Moreover, companies are involved in enhancing their manufacturing capacity for biopharmaceutical development, which in turn is expected to provide avenues of lucrative growth. Other applications of this market include microbial biomass, microbial enzymes, microbial metabolites, biofuels, bioremediation, and bio refineries.

Scale Insights

Depending upon the volume of culture to be produced, bioprocessing carried out can be segmented into two broad categories viz; small and industrial scale. Small-scale bioreactor systems provide parallel processing and allow evaluation of series of experiments for bioprocess optimization by being part of upstream processing. This factor is expected to be supportive for projected growth of small-scale bioprocessing.

Bioprocessing for pharmaceutical development at industrial scale has held the largest share in 2016. Continuous introduction of techniques and tools to support industrial-scale bioprocessing in the market has accelerated industrial scale bioprocessing applications.

For instance, In June 2016, GE Healthcare introduced Capto Q XP chromatography resin. These chromatography resins are strong anion exchanger used to perform purification of large-scale biomolecules in industrial scale. Such initiatives are anticipated to positively influence the growth of this segment over the forecast period.

Use Type Insights

With respect to use type, this market offers multiple-use type and single-use type products. Single-use product-based bioprocessing is expected to witness the fastest growth during the forecast period. It is observed that substantial demand for innovation in single-use instruments, is anticipated to drive growth in this segment in the near future.

Number of advantages associated with single-use products is expected to boost the adoption in this segment. Major advantage associated with single-use type include reduction in the additional expenses associated with assembly, cleaning, process validation, operation, and equipment qualification of multiple use bioprocess equipment.

Multiple-use products for bioprocessing dominated the 2016 market in terms of revenue generation. Low environment impact associated with the implementation of multiple-use instruments and one-time investment is the major factor attributed to its large share in current market.

Mode Insights

Presence of well-established international players in the market, which are capable of performing in-house biopharmaceutical production has led to the large share of in-house biomanufacturing in 2016.

Complexity of biologics is one of the major factors for keeping manufacturing process in-house. Furthermore, companies are using their in-house capabilities as a strategy to maintain the secrecy of their product development processes.

Global large & small-scale bioprocessing (biopharmaceutical manufacturing) market

However, in the future market, outsourced mode of manufacturing is expected to grow lucratively. This is due to the substantial growth in the budgets for outsourcing of biomanufacturing.

In addition, factors such as lack of sufficient expertise, limited capacity to perform industrial scale bioprocess applications, and cost saving advantages associated with contract services are expected provide potential opportunities in outsourcing sector.

Regional Insights

As represented in the above figure, North America is the largest regional market accounting for 27.34% of the overall market revenue share in 2016. The dominance of this region with respect to revenue generation is due to focused cutting-edge R&D in biomanufacturing in the region.

Other key factors which are involved in influencing the progress of market in this region are developed infrastructure and rising funds for bioprocessing technology. Moreover, presence of a substantial number of biomanufacturing facilities in this region has also attributed to the large share of this segment.

However, Asia Pacific is anticipated to be the most attractive regional market space in the coming years. Several companies are outsourcing biologics manufacturing as well as clinical trials in the region which is the key factor to drive progress in this region.

Competitive Insights

Some prominent players operating in the market include Merck KGaA (Sigma-Aldrich Co. LLC), Thermo Fisher Scientific, Inc.; Corning, Inc.; Sartorius AG; CESCO BIOENGINEERING Co., Ltd.; Bio-Process Group; Bioprocess Control AB; Eppendorf AG; Applikon Biotechnology; Lonza; PBS Biotech, Inc; Finesse; Binex Co., Ltd.; Meissner Filtration Products, Inc.; CMC Biologics; CellGenix GmbH; Boehringer-Ingelheim; Patheon; Samsung Biologics; Rentschler Biotechnologie GmbH; TOYOBO Co., Ltd, and Inno Biologics Sdn Bhd.

These participants are undertaking strategic initiatives to retain their significant share as well as to enhance industrial share. Strategic initiatives undertaken by the companies include product line enhancement, regional expansion, distribution network reinforcement, collaborations, and merger & acquisition.

For instance, in November 2016, Finesse Solutions, Inc launched a single-use 3-liter bioreactor vessel SmartVessel to serve biofuels and fermentation applications. This initiative is expected to enhance the company’s status in the coming years.

Report Scope 

Attribute

Details

Base year for estimation

2016

Actual estimates/Historical data

2014 - 2016

Forecast period

2017 - 2025

Market representation

Revenue in USD Billion and CAGR from 2017 to 2025

Regional scope

North America, Europe, Asia Pacific, Latin America, Middle East & Africa

Country scope

U.S., Canada, Germany, France, China, India, Brazil, South Africa

Report coverage

Revenue forecast, company share, competitive landscape, growth factors and trends

15% free customization scope (equivalent to 5-analyst working days)

If you need specific market information, which is not currently within the scope of the report, we will provide it to you as a part of customization


Segments covered in the report

This report forecasts revenue growth at global, regional & country levels and provides an analysis on the industry trends in each of the sub-segments from 2014 to 2025. For the purpose of this study, Grand View Research has segmented the global large & small-scale bioprocessing (biopharmaceutical manufacturing) market on the basis of workflow, product, application, scale, use-type, mode, and region:

  • Scale Outlook (Revenue, USD Billion, 2014 - 2025)

    • Industrial Scale (Over 50,000 Litre)

    • Small scale (Less than 50,000 Litre)

  • Workflow Outlook (Revenue, USD Billion, 2014 - 2025)

    • Downstream Processing

    • Fermentation

    • Upstream Processing

  • Product Outlook (Revenue, USD Billion, 2014 - 2025)

    • Bioreactors/Fermenters

    • Cell Culture Products

    • Filtration Assemblies

    • Bioreactors Accessories

    • Bags & Containers

    • Others

  • Application Outlook (Revenue, USD Billion, 2014 - 2025)

    • Biopharmaceuticals

    • Specialty Industrial Chemicals

    • Environmental Aids

  • Use-type Outlook (Revenue, USD Billion, 2014 - 2025)

    • Multi Use

    • Single Use

  • Mode Outlook (Revenue, USD Billion, 2014 - 2025)

    • In-house

    • Outsourced

  • Regional Outlook (Revenue, USD Billion, 2014 - 2025)

    • North America

      • U.S.

      • Canada

    • Europe

      • Germany

      • France

    • Asia Pacific

      • China

      • India

    • Latin America

      • Brazil

    • Middle East & Africa

      • South Africa

Key questions answered by the report
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