GVR Report cover Single-use Bioprocessing Market Size, Share & Trends Report

Single-use Bioprocessing Market Size, Share & Trends Analysis Report By Product (Probes & Sensors, Simple & Peripheral Elements), By Workflow (Downstream, Upstream), By End-use, By Region, And Segment Forecasts, 2021 - 2028

  • Published Date: May, 2021
  • Base Year for Estimate: 2020
  • Report ID: GVR-2-68038-370-6
  • Format: Electronic (PDF)
  • Historical Data: 2017 - 2019
  • Number of Pages: 225

Report Overview

The global single-use bioprocessing market size was valued at USD 15.8 billion in 2020 and is expected to expand at a compound annual growth rate (CAGR) of 16.0% from 2021 to 2028. Advantages offered by Single-Use Technology (SUT), such as significant reduction in capital cost and facility construction time, have proliferated the use of disposables in the bioprocessing industry. This has resulted in the double-digit growth of the market for single-use bioprocessing.

Germany single-use bioprocessing market size, by product, 2017 - 2028 (USD Million) 

Besides, despite the global economic loss due to the outbreak of the COVID-19 pandemic, the market experienced significant growth. Several CMOs and biomanufacturer have shifted their business focus to the production of therapeutics against SARS-CoV-2 infection using disposable technologies. in September 2020, Serum Institute selected ABEC’s Custom Single Run (CSR) technology to accelerate large-scale, single-use manufacturing of nearly 1.0 billion doses of Novavax vaccine which is designed against COVID-19.

Single-use Systems (SUS) are considered as a commercially viable approach to achieve maximum process efficiency and productivity by several end-users. As a result, SUS equipment is highly employed across the biomanufacturing phases, particularly in pre-commercial biopharmaceutical manufacturing. This has created opportunities for the product suppliers operating in the space.

Furthermore, the rising number of vendors offering robust disposables for commercial manufacturing of biopharmaceuticals is one of the major factors driving the market for single-use bioprocessing. Also, the introduction of automation in the bioprocessing industry has accelerated biomanufacturing efficiency exponentially. Big data analytics is anticipated to be the major trend in the near future.

The introduction of analytical models based on big data machine-learning is anticipated to result in improvement in product yields by enabling prediction and process parameters. Currently, the adoption of disposables is relatively higher among CMOs owing to the ease of use and efficiency of SUTs in bioprocessing of multiple products requiring fast turnaround times.

Product Insights

The simple and peripheral elements segment dominated the market for single-use bioprocessing and accounted for the largest revenue share of 49.0% in 2020. The highest penetration of filters, tubing, transfer systems, and connectors, in terms of product availability and usage, has majorly impacted the revenue generation in this segment. For example, advancements in the single-use system have prompted bioprocess engineers to replace their fixed piping networks with single-use transfer lines.

Furthermore, single-use bags enhance manufacturing reproducibility by offering strength, temperature resistance, and durability. Availability of disposable bioprocess bags in various sizes for several applications helps market players capture untapped avenues of the market and boost their market position.

On the other hand, the demand for disposable probes and sensors is continuously growing within the biopharmaceutical industry. This demand is found to be high across the U.S. and Europe. The emerging and small players are engaged in gaining a competitive edge in this segment by offering single-use sensors for measurement multiple attributes during bioprocessing.

Workflow Insights

The upstream workflow segment dominated the market for single-use bioprocessing and accounted for the largest revenue share of 57.0% in 2020. As compared to downstream processing, single-use systems are commonly available for upstream processes such as media preparation, cell-culture seeding, aseptic sampling, and others. With the increasing disposable bioprocess applications, the industrial suppliers of SUSs are focusing on offering advanced products to overcome the productivity challenges.

Rapid advancements are made by SUT suppliers to advance the implementation of disposables in downstream processing. For instance, the introduction of various disposable unit operation systems for downstream processing such as pre-packed chromatography columns, filtration devices, pumps, and heat exchangers introduction in the market is accelerating the segment growth.

End-use Insights

The biopharmaceutical manufacturers segment dominated the market for single-use bioprocessing and accounted for the largest revenue share of more than 58.0% in 2020. The growing popularity of disposables amongst contract manufacturers has majorly benefitted the biopharmaceutical manufacturing industry. With the growing demand for vaccine manufacturing and related bioprocessing services, several biomanufacturers have begun investing in expanding their manufacturing capabilities with the installation of new disposable equipment to meet the changing customer demands. 

Global single-use bioprocessing market share, by end-use, 2020 (%)

Furthermore, the COVID-19 pandemic has boosted the investment flow in the bioprocessing industry consequently driving the market for single-use bioprocessing. The market players are investing an enormous sum of amount to offer new single-use products such as smart single-use connected temperature sensors to cater to the current market demands. Besides, academic and clinical research institutes are anticipated to witness healthy growth in the near future.

Expanding clinical research activities to decipher the potential of biotherapeutics against various disease areas is expected to have a positive influence on the market for single-use bioprocessing. Also, the presence of institutes such as the National Institute for Bioprocessing Research and Training that offers training and research expertise for the bioprocessing industry is propelling the growth of the segment.

Regional Insights

North America dominated the single-use bioprocessing market with a revenue share of 33.5% in 2020. The expanding biopharmaceutical R&D coupled with the presence of large-scale biopharmaceutical manufacturing facilities in the U.S. has majorly contributed to the dominance of the region. Furthermore, the North America region is home to many contract manufacturing organizations that are engaged in the implementation of disposables in their workflows.

This growing trend has accelerated the investments in this market space. For instance, in January 2021, Fujifilm Diosynth invested USD 2 billion in its U.S. site on a large cell culture production. This site will include eight 20,000-liter bioreactors. In recent years, China has emerged as a potential market for single-use technology with the growing biopharmaceutical manufacturing industry.

Wuxi Biologics is one of the key CDMOs present in China. In February 2021, the company initiated GMP compliant operation in its China facility. This facility employs nine 4,000-liter single-use bioreactors. With China and India at the forefront, this region is anticipated to register the fastest CAGR during the forecast period.

Key Companies & Market Share Insights

Sartorius AG is one of the top players in the market by virtue of its broad product portfolio and customer base. Furthermore, the acquisition of GE Healthcare’s biopharma business by Danaher has boosted the market position of the latter company. In March 2020, GE Healthcare sold its Biopharma business to Danaher Corporation for approximately USD 20 billion in net cash. The biopharma unit is now named Cytiva.

Furthermore, OEMs are engaged in the expansion of their product to capture a solid revenue share of the market for single-use bioprocessing. For instance, In December 2020, Thermo Fisher Scientific introduced the HyPerforma DynaDrive Single-Use Bioreactor (SUB) with improved scalability and performance. This product supports large-scale cell culture processes. Some of the prominent players in the single-use bioprocessing market include:

  • Thermo Fisher Scientific, Inc.

  • Merck KGaA

  • Sartorius AG

  • Corning Incorporated

  • Pall Corporation

  • General Electric Company (GE Healthcare)

  • Eppendorf AG

  • Rentschler Biopharma SE

  • Lonza

  • Meissner Filtration Products, Inc.

  • JM BioConnect

  • Boehringer Ingelheim GmbH

  • Infors AG

  • PBS Biotech, Inc.

  • Entegris, Inc.

  • Danaher Corporation

  • Kuhner AG

  • Rentschler Biopharma SE

Single-use Bioprocessing Market Report Scope

Report Attribute

Details

Market size value in 2021

USD 19.4 billion

Revenue forecast in 2028

USD 51.9 billion

Growth Rate

CAGR of 16.0% from 2021 to 2028

Base year for estimation

2020

Historical data

2017 - 2019

Forecast period

2021 - 2028

Quantitative units

Revenue in USD Million and CAGR from 2021 to 2028

Report coverage

Revenue forecast, company share, competitive landscape, growth factors, and trends

Segment covered

Product, workflow, end-use, region

Regional scope

North America; Europe; Asia Pacific; Latin America; MEA

Country scope

U.S.; Canada; Germany; France; Italy; Spain; U.K.; China; Japan; India; South Korea; Brazil; Mexico; South Africa; Saudi Arabia

Companies profiled

Thermo Fisher Scientific, Inc.; Merck KGaA; Sartorius AG; Corning Incorporated; Pall Corporation; General Electric Company (GE Healthcare); Eppendorf AG; Rentschler Biopharma SE; Lonza; Meissner Filtration Products, Inc.; JM BioConnect; Boehringer Ingelheim GmbH; Infors AG; PBS Biotech, Inc.; Entegris, Inc.; Danaher Corporation; Kuhner AG; Rentschler Biopharma SE

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Segments Covered in the Report

This report forecasts revenue growth at global, regional, and country levels and provides an analysis of the latest industry trends in each of the sub-segments from 2017 to 2028. For the purpose of this study, Grand View Research has segmented the global single-use bioprocessing market report on the basis of product, workflow, end-use, and region:

  • Product Outlook (Revenue, USD Million, 2017 - 2028)

    • Simple & Peripheral Elements

      • Bags

      • Tubing, Filters, Connectors, & Transfer Systems

      • Sampling Systems

      • Probes & Sensors

        • pH Sensor

        • Oxygen Sensors

        • Pressure Sensors

        • Temperature Sensors

        • Conductivity Sensors

        • Flow Sensors

        • Other sensors

      • Others

    • Apparatus & Plants

      • Bioreactors, By Capacity

        • Up to 1000L

        • Above 1000L to 2000L

        • Above 2000L

      • Filtration system

      • Mixing, Storage, & Filling Systems 

      • Chromatography Systems

      • Pumps

      • Others

    • Work Equipment

      • Cell Culture System

      • Syringes

      • Others

  • Workflow Outlook (Revenue, USD Million, 2017 - 2028)

    • Upstream

    • Fermentation

    • Downstream

  • End-use Outlook (Revenue, USD Million, 2017 - 2028)

    • Biopharmaceutical Manufacturer

      • CMOs & CROs

      • In-house Manufacturer

    • Academic & Clinical Research Institutes

  • Regional Outlook (Revenue, USD Million, 2017 - 2028)

    • North America

      • U.S.

      • Canada

    • Europe

      • Germany

      • France

      • Italy

      • Spain

      • U.K.

    • Asia Pacific

      • China

      • India

      • Japan

      • South Korea

    • Latin America

      • Brazil

      • Mexico

    • Middle East & Africa

      • South Africa

      • Saudi Arabia

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