GVR Report cover Trypsin Market Size, Share & Trends Report

Trypsin Market Size, Share & Trends Analysis Report By Source (Porcine, Bovine), By Application (Biotechnology & Pharmaceutical Industry, Food Industry), By End-use, By Region, And Segment Forecasts, 2024 - 2030

  • Report ID: GVR-4-68040-273-6
  • Number of Report Pages: 125
  • Format: PDF, Horizon Databook
  • Historical Range: 2018 - 2022
  • Forecast Period: 2024 - 2030 
  • Industry: Healthcare

Trypsin Market Size & Trends

The global trypsin market size was estimated at USD 91.6 million in 2023 and is projected to grow at a CAGR of 5.3% from 2024 to 2030. Trypsin is an enzyme that plays a crucial role in protein digestion. The increasing adoption of trypsin across various industries, such as pharmaceuticals, food science research, detergents, and leather-bating, is likely to drive market growth, whereas the increasing focus on drug discovery and development is further propelling market growth.

U.S. Trypsin Market size and growth rate, 2024 - 2030

The use of trypsin in food and pharmaceutical manufacturing is governed by innovation of new techniques and various studies around it, in April 2020, a study published by microbial cell factories, highlights trypsin such as Microbial Streptomyces griseus trypsin (SGT), was investigated specifically for its high efficacy of hydrolysis. Interestingly, SGT protein could serve as such a source of trypsin for insulin. Therefore, hydrolysates analysis and direct selection led to the effectiveness of the trypsin (K101A) adaptive mutant, the presented study facilitated a rise in the production of trypsin. These types of research and developments are poised for market growth.

Recently, in February 2022, the International Agency for Research on Cancer (IARC), published the statistics, that during the pandemic, new colon cancer cases were around 1.15 million. Further, this number is expected to rise to 1.82 million by the year 2040 and around an increase of 56% between 2020 and 2040, to more than 3 million new cases per year can be observed over the coming years. Similarly, trypsin is also used to treat other cancers as it could have tumor-suppressive properties. This is anticipated to contribute to a heightened demand for trypsin related studies and therapeutics, which would help the drive market growth in the forecast period.

Trypsin is widely being used in the R&D in pharmaceutical, food, and environmental industries, owing to its special digestive functions of hydrolyzing proteins. It acts as a raw material for internal medicine used in endocrine diseases and clinical surgery. The use of enzyme catalysts has been scaled up for commercial processes in the pharmaceutical, beverages, and food industries. These enzymes help in waste reduction, which makes them highly efficient to be used in food, pharmaceuticals, and feed industries. Moreover, the best source of trypsin, TRYPSIN VI, has found nutraceutical use as an anti-inflammatory treatment and a digestive supplement for veterinary & human applications.

Various research studies are being conducted to evaluate its potential in diagnosing a wide range of disorders, such as cancer, acute pancreatitis, malabsorption, and cystic fibrosis. Increase in R&D expenditure, the rising drug launches, and FDA approvals. For instance, in October 2022, Phathom Pharmaceuticals collaborated with Evonik in a deal to manufacture its recently FDA-approved gastrointestinal drug, vonoprazan, which is approved for the treatment of gastric acid-related diseases. Thus, such factors can provide ample opportunities in the global market during the forecast period

Market Concentration & Characteristics

The degree of innovation in the market is characterized by moderate-to-high levels of innovation, including the frequent development and introduction of novel techniques such as, bovine trypsin made in maize seed concluded in a commercial source called TrypZean, which is studied further as a probable replacement source for use in cell culture and use of heterologous expression (producing trypsin using alternative hosts) is also being investigated to address challenges associated with traditional extraction methods. Key players are also investing in innovative methods such as extraction and use of trypsin from marine aquaculture gut bacteria to meet the global demand of the market.

Trypsin Market Concentration & Characteristics

The market is characterized by the leading players with moderate levels of source launches and merger and acquisition (M&A) activity. Market players like Novozymes, Agilent Technologies and Thermo Fisher Scientific are involved in new source launches and merger and acquisition activities. For instance, in 2021, For instance, in June 2021, MEDISCA partnered with Sichuan Deebio Pharmaceutical Co., which exports animal extracts including trypsin. This partnership provided thyroid-APIs to non-compounding and compounding industries. Several players engage in mergers & acquisitions to strengthen their market position. This strategy enables companies to increase their capabilities, expand their source portfolios, and improve competency.

The regulatory framework for source approvals has always been one of the major restraining factors in the pharmaceutical, biotechnology, and medical technology industries. The regulatory framework for the diagnostic sector is very stringent in countries where the market has high potential to grow due to the availability of a larger application and research area.

The level of substitution is generally moderate for the market, as recombinant trypsin solutions that might replace porcine trypsin and avoid animal-related variability and contamination are yet in their developmental stages.

End user concentration is high with regards to research and diagnostics industry as trypsin is widely being used in R&D in pharmaceutical, food, and environmental industries, owing to its special digestive functions of hydrolyzing proteins. It acts as a raw material for internal medicine and clinical surgery. The use of enzyme catalysts has scaled up for commercial processes in the pharmaceutical, beverages, and food industries

Source Insights

Based on source, the bovine segment led the market with the largest revenue share of 60.07% in 2023, due to its specific cleavage activity, bovine trypsin has found numerous applications in various fields. Although, bovine trypsin is readily available and relatively inexpensive compared to other proteases Animal-derived trypsin is used for vaccine sourceion, research laboratories, such as Sisco Research Laboratories, use bovine trypsin for cell culture. Similarly, several bovine trypsin sources are offered by Merck Millipore, Thermo Fisher Scientific and others that are suited for cell culture and have a wide range of applications. Furthermore, increased adoption of trypsin for R&D in academic and pharmaceutical industries is likely to boost market growth.

The Porcine segment are anticipated to witness the fastest CAGR over the forecast period. Porcine trypsin is used in manufacturing vaccines, including against influenza, chickenpox, polio, and rotavirus. Although animal-based sources were used in development and sourceion of vaccines, current usage has been kept to an absolute minimum. It is only considered if it ensures the effectiveness and safety of vaccines and is provided in a highly regulated way

End-use Insights

Based on end-use, the industrial use segment led the market with the largest revenue share of 83.1% in 2023. This is attributable to the growing use of trypsin in detergents, leather bating, and the food & pharmaceutical industries. In detergents, trypsin is used to break down protein-based stains like blood, egg, and other organic matter. However, its use in detergents has been limited due to concerns about its safety and environmental impact and in food & pharmaceutical industries, it is used to improve functional properties such as emulsification, foaming, solubility, and gelling properties of food proteins.

Global Trypsin Market share and size, 2023

The research segment is anticipated to grow at the fastest CAGR over the forecast period. Trypsin is used for cell harvesting in cell culture preparation. These are specifically used for detachment of adherent cells from cell culture flasks. Besides various applications of trypsin for pharmaceutical and nutritional purposes, trypsin from natural sources is mostly used in molecular biology practice. The demand for trypsin has increased owing to developments in proteomics research and technological advancements & innovations in R&D by various companies & research institutes. For instance, in January 2024, Ensysce Biosciences has announced about receiving FDA breakthrough for developing a new class of tamperproof opioids by using trypsin-activated abuse protection & multipill abuse resistance. The company’s source would provide better & safer prescription options to treat pain and assist in preventing death because of opioid abuse.

Application Insights

Based on application, the biotechnology and pharmaceutical segment led the market with the largest revenue share of 56.2% in 2023. Trypsin is employed in high-throughput screening methods to study the interactions between proteins and potential drug candidates. It helps in understanding the structure-function relationships of target proteins, aiding in the development of novel therapeutics. For instance, Thermo Scientific’s Pierce Trypsin Protease, MS Grade, a highly purified with chemical modification to enhance its activity and stability in proteomic applications. The enzyme is treated with (Tosyl phenylalanyl chloromethyl ketone) TPCK and methylated to increase digestive stability as it loses chymotrypsin activity.

The biotechnology and pharmaceutical segment is also expected to register the fastest CAGR during the forecast period. The pharmaceutical sector is one of the most innovative industries in various countries; companies are investing in the market to develop natural high-quality enzymes and proteins. For instance, Novea Technologies, Inc. produces APIs using pancreatic enzymes for compliant food solutions. Diagnostic media and functional food ingredients can be used for the development of infant formulas and nutraceutical sources. The company manufactures Trypsin 1:250 derived from porcine pancreas for cell culture applications. Diverse applications of trypsin without possessing any adverse effects can increase the adoption of enzymes by pharmaceutical companies, thereby boosting market growth.

Regional Insights

North America dominated the trypsin market with the revenue share of 40.7% in 2023. This high share is attributable to local presence of key market players, such as Bio-Rad Laboratories, Creative Enzymes, Hawkins, Agilent Technologies, Promega Corporation, and Thermo Fisher Scientific. Moreover, several collaborations and partnerships among companies have contributed to regional market growth. Furthermore, increase in incidence of pancreatitis, cystic fibrosis, and cancer in the region may result in a greater demand for trypsin in the diagnostic field. For instance, in November 2022, according to American lung Association, highlights about 30,000 cystic fibrosis cases in the U.S. and estimated 1 in 30 Americans is a carrier. In addition, enzyme therapy may show promising results in growth inhibition of tumor cells with metastatic potential as trypsin exhibits a tumor-suppressive role in cancer progression. Such factors are poised to propel the trypsin market.

Trypsin Market Trends, by Region, 2024 - 2030

U.S. Trypsin Market Trends

The trypsin market in the U.S. is expected to grow at the fastest CAGR over the forecast period, due to advancements in therapeutics, for instance, Merck Millipore, a prominent player in the U.S., offers various Tumor-Associated Trypsin Inhibitor (TATI) sources. TATI is a prognostic marker in treating colorectal cancer. TATI, when mixed with trypsin in some forms of cancer, can reduce tissue destruction by blocking trypsin and other proteases with favorable diagnosis. These advancements in the field can further fuel the demand for trypsin over the forecast period.

Europe Trypsin Market Trends

The trypsin market in Europe is expected to grow at a lucrative CAGR during the forecast period. The market growth of region can be attributed to local presence of key market players in this region. In June 2021, according to a safety analysis published by European Food Safety Analysis (EFSA), the food enzyme trypsin from porcine pancreas, used in hydrolyzing whey protein and infant formula, was considered low likelihood of allergic sensitization to the after consumption of the food enzyme. This is one of the major factors contributing to the region’s market growth.

The UK trypsin market is expected to grow at the fastest CAGR over the forecast period, due to large scale research studies being published by various institutes on usage of exogenous trypsin enzymes for R&D. According to a study published by Public Health England, porcine trypsin is widely used to by key players to manufacture vaccines.

The trypsin market in France is anticipated to witness at a significant CAGR over the forecast period, owing to increasing use of trypsin to produce dairy sources, such as yogurt, cheese, and flavored milk. The flourishing dairy industry and increased cheese source ion in France are projected to have a positive impact on the demand for trypsin. Some of the leading players in France's trypsin market are BASF SE, Novozymes A/S (Novozymes Biologicals, FR S.A.), Advanced Enzyme Technologies Ltd., Adisseo, and Amano Enzyme Inc.

The Germany trypsin market is expected to grow at the fastest CAGR over the forecast period. With the ongoing developments in the regions, such as the German Cancer Research Center (DKFZ) is working on developing new diagnostic methods and some of the leading suppliers in the region manufacture enzymes, as wholesale and for foreign trade, which are to be used for APIs. For instance, BIOZYM Gesellschaft offers Pancreatin trypsin manufactured from porcine pancreas to the UAE, EU countries, and Asia Pacific countries. Many enzyme exports to foreign countries is expected to increase trypsin market revenue in the region.

Asia Pacific Trypsin Market Trends

The trypsin market in Asia Pacific is anticipated to witness the fastest CAGR during the forecast period. Industrial growth has been a driving force in the economic growth of the countries in the region. Moreover, a large number of population in the region faces wounds and injuries. According to WHO, burns are a global health problem, and 180,000 estimated deaths occur every year. The highest prevalence was observed in Southeast Asia and Western Pacific region. The low- and middle-income countries account for more than 90% of mortality owing to poverty and lack of infrastructure. There has been no breakthrough in burn treatment, and with increased resistance to bacteria management of burns, cases have become more complicated. Therefore, therapies are aimed at controlling inflammation by providing supplementation with oral hydrolytic enzymes mainly trypsin. These factors can further increase the demand for trypsin in this region.

The China trypsin market is expected to grow at the fastest CAGR over the forecast period, due to rise in per capita income leading to increased adoption of diagnostic and therapy sources coupled with technological breakthroughs, standardized management, increased acceptance of green source ion, increased R&D investment, and increased collaboration between industry & universities are contributing to the region's growth.

The trypsin market in Japan is expected to grow at the fastest CAGR over the forecast period, as the Japan stands second after the U.S. in its share of biotherapeutic approvals and new therapeutics launch. These developments and advancements in the field of the bioprocessing industry in the region can fuel the demand for trypsin as it provides stability and quality sources with increased source ion efficiency.

Latin America Trypsin Market Trends

The trypsin market in Latin America is likely to grow at the fastest CAGR during the forecast period, due to various factors. Rising investments in the overall healthcare field, growing awareness about enzyme-based therapies, and a growing pharmaceutical industry is likely to drive the growth. The region's growing population and higher rates of chronic diseases also contribute to the demand for trypsin products.

The Brazil trypsin market is expected to grow at the fastest CAGR over the forecast period, due to increasing aging population, growing health conscience consumers, increasing popularity, and the COVID-19 pandemic have led people to look for immune boosting. Trypsin helps regulate metabolic functions and maintains energy levels. Moreover, researchers suggest the use of trypsin when it comes to inflammatory response.

Middle East & Africa Trypsin Market Trends

The trypsin market in Middle East & Africa is anticipated to grow at the fastest CAGR during the forecast period. The increasing investments in R&D and healthcare infrastructure development in the Middle East and Africa are further boosting the market for trypsin within the region. The need for trypsin-based treatments has been increasing which has been a major market driver. Developments in enzyme engineering are enhancing the effectiveness of trypsin, making it valuable in industries beyond healthcare, such as food processing and research. Government initiatives supporting biotech research and development are also fueling market expansion. Consequently, the Middle East and Africa present promising opportunities for companies involved in the production and distribution of trypsin.

The Saudi Arabia trypsin market is expected to grow at the fastest CAGR over the forecast, period due to increasing awareness about trypsin's accelerating chemical reactions and its wide range of applications across various industries, as well as delivering environmentally acceptable solutions, can help the market grow rapidly. Several Saudi Arabia based companies are collaborating with international players, giving them access to advanced technology, distribution, & expertise.

Key Trypsin Company Insights

Some of the key players operating in the market include Merck Millipore, Novozymes, Agilent Technologies, Thermo Fisher Scientific, Sartorius AG, PromoCell GmbH, and Promega Corporation

The market is highly competitive, with a large number of manufacturers accounting for a majority of the share. New source developments, mergers and acquisitions, and collaborations are some of the major strategies adopted by these players to counter the stiff competition.

Neova Technologies, BBI Solutions, and Linzyme Biosciences are some of the emerging market participants in the global market. These companies focus on achieving funding support from government bodies and healthcare organizations aided with novel source launches to capitalize on untapped avenues.

Key Trypsin Companies:

The following are the leading companies in the trypsin market. These companies collectively hold the largest market share and dictate industry trends.

  • Merck Millipore
  • Novozymes
  • Agilent Technologies
  • Thermo Fisher Scientific
  • Sartorius AG
  • Neova Technologies
  • BIOZYM
  • PromoCell GmbH
  • Promega Corporation
  • Bovogen Biologicals
  • Zymetech
  • BBI Solutions
  • Linzyme Biosciences

Recent Developments

  • In January 2023, Sun Pharma India completed acquisition and buyout of Disperzyme and Phlogam brands from Aksigen, these are the first combinations of enzyme-bioflavonoid which have completed a scientific study and got DCGI approval in India and are intended for patients who are undergoing minor surgery for controlling the inflammatory process

  • In March 2023, Water Corp introduced its RapiZyme Trypsin, It was found out that this chemically improved recombinant new trypsin provide top standard reliability while decreasing the digestion time down from over three hours to a mere 30 minutes

Trypsin Market Report Scope

Report Attribute

Details

Market size value in 2024

USD 96.2 million

Revenue forecast in 2030

USD 131.5 million

Growth rate

CAGR of 5.3% from 2024 to 2030

Base year for estimation

2023

Historical data

2018 - 2022

Forecast period

2024 - 2030

Quantitative units

Revenue in USD million/billion and CAGR from 2024 to 2030

Report coverage

Revenue forecast, company ranking, competitive landscape, growth factors, and trends

Segments covered

Source, application, end-use, region

Regional scope

North America; Europe; Asia Pacific; Latin America; MEA

Country scope

U.S.; Canada; UK; Germany; France; Italy; Spain; Sweden; Denmark; Norway; China; Japan; India; Australia; South Korea; Thailand; Brazil; Mexico; Argentina; Saudi Arabia; South Africa; UAE; Kuwait

Key companies profiled

Merck Millipore; Novozymes; Agilent Technologies; Thermo Fisher Scientific, Inc.; Sartorius AG; Promega Corporation; Bovogen; Biologicals; Zymetech; BBI Solutions; Neova Technologies; BIOZYM; PromoCell GmbH; Linzyme Biosciences

Customization scope

Free report customization (equivalent up to 8 analyst’s working days) with purchase. Addition or alteration to country, regional & segment scope

Pricing and purchase options

Avail customized purchase options to meet your exact research needs. Explore purchase options

Global Trypsin Market Report Segmentation

This report forecasts revenue growth at global, regional, and country levels and provides an analysis of the latest industry trends in each of the sub-segments from 2018 to 2030. For this study, Grand View Research has segmented the global trypsin market report based on source, application, end-use, and region:

Global Trypsin Market Report Segmentation

  • Source Outlook (Revenue, USD Million, 2018 - 2030)

    • Porcine

    • Bovine

    • Others

  • Application Outlook (Revenue, USD Million, 2018 - 2030)

    • Biotechnology and Pharmaceutical Industry

    • Food Industry

    • Cosmetics and Personal Care

    • Waste Treatment

    • Others

  • End-use Outlook (Revenue, USD Million, 2018 - 2030)

    • Research

    • Diagnostics

    • Industrial use

  • Regional Outlook (Revenue in USD Million, 2018 - 2030)

    • North America

      • U.S.

      • Canada

    • Europe

      • UK

      • Germany

      • France

      • Italy

      • Spain

      • Russia

      • Sweden

      • Denmark

      • Norway

    • Asia Pacific

      • Japan

      • China

      • India

      • Australia

      • South Korea

      • Singapore

      • Thailand

    • Latin America

      • Brazil

      • Mexico

      • Argentina

    • Middle East and Africa

      • Saudi Arabia

      • South Africa

      • UAE

      • Kuwait

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