Cell Culture Protein Surface Coating Market Size, Share & Trends Analysis Report By Coating Type (Self-coating, Precoating), By Protein Source (Animal-derived, Synthetic), By Region, And Segment Forecasts, 2022- 2030

Report Overview

The global cell culture protein surface coating market was valued at USD 701.9 million in 2021 and is expected to expand at a compound annual growth rate (CAGR) of 15.3% from 2022 to 2030. The increasing interest of scientists and biotechnology companies in stem cell research is a major factor driving the industry growth. Cell culture protein surface coating provides improved development and cell adhesion in in-vitro cell culture. Thus, the demand for these products is increasing, thus creating revenue generation opportunities. A stem cell is a very effective and promising therapy to treat several severe diseases including neurological diseases, cancer, Cardiovascular Diseases (CVDs), and cell deficiency.

For instance, Parkinson's and Alzheimer's disease can be treated by replacing damaged cells and tissues. In the context of COVID-19, various government organizations, research institutes, and pharmaceutical & biotech firms are focusing on rapid and effective technologies for developing vaccines/novel therapeutics and diagnosis of COVID-19 to overcome the situation. For instance, researchers from UVE (Unité des Virus Émergents) screened 1,520 USFD-approved drugs for their anti-viral properties using Caco-2 and VeroE6 immortalized cell lines. From this study, researchers recognized 90 compounds spanning distinct drug categories, such as proton pump inhibitors and antibiotics, that might be therapeutically relevant to treat COVID-19.

Similarly, researchers from the Institute for Molecular Medicine Finland made use of VeroE6 cell lines and found that a combination of host-directed amodiaquine and orally available virus-directed nelfinavir unveiled the finest therapeutic effects against COVID-19 across 136 broad range antiviral products. Such developments significantly increased the demand for culture products during the COVID-19 pandemic. The rising interest of researchers and biotechnology companies in stem cell research is one of the key factors driving the industry's growth. Stem cells have become a potential tool for the treatment of several disorders, such as osteoarthritis, heart failure, and eye diseases.

Regenerative medicine has revolutionized the research in science and technology by growing entirely new organs and tissues outside the body by taking cells from patients. This would further increase the demand for regenerative medicine for the treatment of diseases. With constant development in therapies, several new advanced cell culture protein surfaces have emerged. Advancements in the research and development field would further fuel industry growth in the coming years. The protein surfaces offer better growth and adhesion in cell culture. Gelatin is usually used in the culture of muscle, Embryonic Stem (ES) cells, and vascular endothelial cells, among others.

Corning Inc., one of the leading players, offers a wide range of cell culture protein surfaces and substrates, which enable cell attachment under difficult conditions. For instance, the company offers BioCoat Gelatin cultureware, which offers attachment and growth-promoting substrate for the culture. Moreover, in the past few years, cell culture has evolved and is widely used as a bioproduction and research tool. The protein surfaces used for growing cells have progressed rapidly, as the need for researchers has changed. Several breakthrough studies have helped with the advancement of the culture medium, resulting in a significant rise in the use of cell culture.

The other drivers include the growing demand for targeted therapy and protein therapeutics along with an increasing preference for 2D and 3D cell cultures. 3D cell culture is a process of growing biological cells in a controlled condition, where cells could interact with the surrounding cells across all dimensions. The protein-coated instruments offer a 3D microenvironment to attain proper proliferation and cell adhesion. For instance, Agilent Technologies offers automated imaging tools that could provide significant information to improve routine culture techniques and increase the reproducibility and effectiveness of downstream cell-based assays.

Coating Type Insights

Based on coating types, the global industry has been further segmented into precoating and self-coating. In 2021, the self-coating segment dominated the global industry and accounted for the highest share of more than 60.00% of the overall revenue. The rising investment in research and development is a key factor boosting segment growth. The biotechnology and biopharmaceutical companies are focusing on the production of monoclonal antibodies, protein therapeutics, induced pluripotent stem cell research, and cryobanking. Thus, the demand for self-coating is also expected to remain high during the study period.

On the other hand, the precoating segment is expected to register the fastest growth rate during the forecast period. This segment is further classified into multiwall/microwell plates, flasks, Petri dishes, slides, and cover slips. The precoated culturewares provides several advantages, such as it is ready-to-use, saves time, delivers consistent quality, and improves isolation and cultivation. Thus, the popularity of precoating culturewares is increasing. This, in turn, is projected to boost the growth of the precoating segment.

Protein Source Insights

Based on protein sources, the global industry has been further categorized into animal-derived, human-derived, synthetic, and plant-derived proteins. The animal-derived material segment dominated the global industry in 2021 and accounted for the highest share of more than 40.15%of the overall revenue. The major application of these products in the production of biopharmaceuticals including monoclonal antibodies and recombinant proteins is the most predominant factor contributing to its highest share. On the other hand, the demand for human-derived protein products is also high due to their large application in insulin production.

The increasing incidence of diabetes drives the demand for insulin. Thus, the rising incidence of diabetes boosts the growth of the human-derived protein segment. On the other hand, the synthetic material segment is expected to exhibit the fastest growth rate during the forecast period. The growing demand for animal-free components is a prime factor attributing to the growth of this segment. Ethical and religious constraints on the application of animal-derived protein propel the adoption of synthetic protein coatings.

Regional Insights

North America dominated the overall industry and accounted for the largest share of more than 36.85% in 2021. The highly developed healthcare & research infrastructure and focus on drug discovery in the region have fueled the region’s growth. The U.S. dominated the regional market of North America owing to the rapid technological advancements, increasing approval for cell culture-based vaccines, growth in pharmaceutical and biotechnology industries, strong government support, high funding in cell-based research, and growing incidence of diseases, such as cancer.

For instance, in May 2022, Blue Water Vaccines, Inc. collaborated with the multidisciplinary Center for Research and Development in Immunobiologics, which aims to develop influenza vaccine candidates based on cell culture and adjuvant formulation-based vaccines. Asia Pacific is expected to register the fastest CAGR during the study period due to untapped opportunities in the region. China is anticipated to witness significant growth in the coming years owing to the presence of several biopharmaceutical companies and clinical research organizations in the country working towards drug discovery and development.

The untapped opportunities in the country are attracting international players to invest in the country’s market. For instance, in October 2020, Merck KGaA collaborated with D1Med a Shanghai-based biopharmaceutical company, that aims to advance the 3D cell culture technology in China, which could be used in the drug discovery process. Moreover, with favorable government policies and growing R&D investments, the country is witnessing a surge of innovative biotech and pharma companies.

Key Companies & Market Share Insights

Key players are adopting various organic and inorganic strategies, such as partnerships, mergers and acquisitions, geographical expansion, and strategic collaborations to expand their industry presence. For instance, in January 2022, Thermo Fisher Scientific Inc. acquired PeproTech. PeproTech’s recombinant protein range complements the cell culture products of Thermo Fisher and will allow Thermo Fisher to offer customers substantial benefits through a combined offering. Some of the key players in the global cell culture protein surface coating market include:

• Thermo Fisher Scientific   

• Corning, Inc.

• Merck Millipore

• Promega Corp.

• Sartorius AG

• Greiner Bio-One International GmbH

• PerkinElmer, Inc.

• BioVision, Inc.

• Trevigen, Inc.

• Viogene

Cell Culture Protein Surface Coating Report Scope

Global Cell Culture Protein Surface Coating Market Segmentation

This report forecasts revenue growth at global, regional, and country levels and provides an analysis of the latest industry trends in each of the sub-segments from 2018 to 2030. For this study, Grand View Research has segmented the global cell culture protein surface coating market report based on coating type, protein source, and region:

• Coating Type Outlook (Revenue, USD Million, 2018 - 2030)

  • Self-coating

  • Precoating

    • Multiwall/microwell plates

    • Petri dishes

    • Flasks

    • Slides

    • Cover slips

• Protein Source Outlook (Revenue, USD Million, 2018 - 2030)

  • Animal-derived

  • Human-derived

  • Synthetic

  • Plant-derived

• Regional Outlook (Revenue, USD Million, 2018 - 2030)

  • North America

    • U.S.

    • Canada

  • Europe

    • Germany

    • U.K.

    • France

    • Italy

    • Spain

  • Asia Pacific

    • China

    • India

    • Japan

    • South Korea

    • Australia

  • Latin America

    • Brazil

    • Mexico

    • Argentina

  • MEA

    • South Africa

    • Saudi Arabia

    • UAE