Single-cell Analysis Market Size, Share & Trends Analysis Report By Product (Consumables, Instruments), By Application (IVF, Cancer, Stem Cell), By Workflow, By End-use, By Region, And Segment Forecasts, 2021 - 2028

Report Overview

The global single-cell analysis market size was valued at USD 2.2 billion in 2020 and is expected to expand at a compound annual growth rate (CAGR) of 15.0% from 2021 to 2028. An increase in investments and government funds deployed for research and development (R&D) in the field of medical diagnostics, availability of technically advanced products, and the rising adoption of single-cell analysis devices are some factors that can be attributed to the growth of the market.

Moreover, the advent of technology in single-cell amplification and manipulation techniques has led to the application of high throughput technologies in assays, thereby propelling revenue growth. In addition, the rapid development of microfluidic devices has significantly broadened the implementation of single-cell genomic/transcriptomic analysis in the biomedical field.

Technological advancements in sequencing techniques are transforming the landscape of single-cell omics research activities, including transcriptomic, epigenomics, and genomics. Significant advancements in sequencing reproducibility coupled with declining costs have helped process a large number of samples.

Increasing demand for analytical tools and technological advancements has led to the introduction of high-throughput machinery in the market. Several innovations have led to the introduction of new features such as high sensitivity, accuracy, and efficacy by utilizing scarce samples. Thus, key players are investing a significant amount in the development of solutions leading to a lucrative opportunity for revenue generation in the near future.

The ongoing pandemic of COVID-19 has triggered the adoption of single-cell analysis methods in virology research. The researchers are using these techniques to understand the immune profiles of infected patients. For instance, in a study published in January 2021, researchers from China performed high-dimensional single-cell analysis to understand the peripheral immune response to the COVID-19 infection.

Product Insights

The consumables segment dominated the market and accounted for the largest revenue share of 57.1% in 2020 due to the high usability of products and frequent purchase of reagents, large-scale adoption of beads, and growing demand for assay kits. An increase in the prevalence of target diseases and the constant need for consumables required for the assays is propelling segment growth.

Moreover, reagents are consumables that are extensively used throughout cell analysis assays and hence the demand is always high. These reagents are available in different forms including multicolor cocktails, probes, markers, and phenotyping agents. As a result, the adoption and purchase of reagents lead to revenue generation in the market.

On the other hand, installation of new instruments and replacement of old instruments led to revenue generation for the instruments segment. Owing to the high-end features and the technically advanced analytical options, the automated instruments contributed to the substantial revenue in the market.

Application Insights

The cancer segment dominated the market and accounted for the largest revenue share of more than 30.0% in 2020. Single-cell analysis has proved to be effective for prior diagnostics of cancer cells, thus driving the segment. The mutation rates, proliferation conditions of cells, and cell types can be easily identified using these techniques.

The presence of a substantial number of research entities engaged in evaluating single-cell genomics and proteomics for the investigation of various therapeutic areas such as neuroscience, cancer, and infectious diseases has led to increasing adoption of single-cell analysis methods in diagnostics and therapeutic applications.

Increasing adoption of stem cell therapies is proving beneficial to the single-cell analysis market. The extensive application area of stem cell therapies is widening the scope of stem cell genomics, proteomics, and epigenetics. The therapies like regeneration of hair, bone marrow transplant, and organ transplants are boosting the adoption rates of single-cell analysis techniques.

Workflow Insights

The single-cell isolation and library preparation segment dominated the market and accounted for the largest revenue share of 25.8% in 2020. Given the wide range of single-cell applications, the demand for cell isolation and library preparation products (kits and reagents) is also high. In addition, a substantial number of companies are offering products in this segment, in turn, augmenting revenue growth.

On the other hand, owing to technological advancements such as the emergence of next-generation sequencing for analyzing cell expressions, the downstream analysis segment is gaining traction over the past few years. Also, the market is witnessing an increasing adoption of machine learning and artificial intelligence in data analysis.

Several computational methods have been developed and are being employed owing to their benefits such as scalability, flexibility, and high success rates. Thus, the high employment of such data analysis tools would spur market growth in the near future.

End-use Insights

In 2020, the academic and research laboratories segment dominated the market and accounted for the largest revenue share of over 70.0%. Single-cell analysis technology is being widely employed in research settings. The substantial number of ongoing research projects at universities that employ single-cell analysis assays have led to increased adoption of various single-cell analyses at research settings.

The advent of spatial genomics that accelerates the single-cell analysis in research settings is another key factor driving the segment growth. Academic researchers are engaged in assessing spatial heterogeneity in gene expression profiles at a single cellular level. Furthermore, single-cell transcriptomics is found to be useful for neuroscientists to understand cell types forming the brain.

Technological advancements such as the use of microfluidics for the development of next-generation therapies have increased the adoption of single-cell analysis by biotechnology and pharmaceutical companies. Moreover, increasing penetration of genomic technologies in drug development would further drive the market. A substantial number of pharma firms have invested in genomics to have an access to various genomics databases.

Regional Insights

North America dominated the single-cell analysis market and accounted for the largest revenue share of 35.0% in 2020. This can be attributed to factors such as high government funding, rising personal healthcare expenditure, improved awareness, speedy adoption of novel analytical techniques, and the availability of skilled personnel.

The U.S. is the major contributor to the dominance of North America. Exceptionally developed healthcare infrastructure, rising expenditure on personalized medicine, growing awareness amongst citizens, and an increase in government and private funding for the research projects are some key driving factors for the market.

In the past few years, factors such as the booming medical tourism industry, rapidly developing healthcare infrastructure, and increasing disposable income have resulted in fueling the demand for advanced diagnostic tools in emerging economies of Asia Pacific. The focused efforts are expected to drive the market in the region and account for the highest CAGR over the forecast period.

Key Companies & Market Share Insights

The key companies have focused on the development of innovative and technologically advanced products to fulfill consumer demands. For instance, in February 2021, SeqWell Inc. launched plexWell Single Cell Rapid Kit for single-cell RNA sequencing. It is used for the simplified preparation of NGS libraries. Furthermore, the company has signed a distribution agreement with CELLINK AB in February 2021 for the commercialization of its products to expand its presence outside the U.S. Such company initiatives are expected to intensify market competition.

This market space is continuously growing for the past few years owing to the increasing uptake of these techniques for diagnostic applications. The growing prevalence of genetic disorders has resulted in an increasing need for early diagnosis. This has created lucrative opportunities for emerging players to capture untapped avenues of the market. Some of the prominent players in the single-cell analysis market include:

• Thermo Fisher Scientific Inc.

• QIAGEN NV

• Bio-Rad Laboratories Inc.

• Illumina Inc.

• Merck Millipore

• Becton

• Dickinson & Company

• Fluidigm Corporation

• 10x Genomics, Inc.

• BGI

• Novogene Corporation

Single-cell Analysis Market Report Scope

Segments Covered in the Report

This report forecasts revenue growth at global, regional, and country levels and provides an analysis of the latest industry trends in each of the sub-segments from 2017 to 2028. For the purpose of this study, Grand View Research has segmented the global single-cell analysis market report on the basis of product, application, workflow, end-use, and region:

• Product Outlook (Revenue, USD Million, 2017 - 2028)

  • Consumables

    • Reagents

    • Assay Kits

  • Instruments

    • Microscope

    • Hemocytometers

    • Flow Cytometers

    • NGS Systems

    • PCR

    • High Content Screening Systems

    • Cell Microarrays

    • Single Live Cell Imaging

    • Automated Cell Counters

• Application Outlook (Revenue, USD Million, 2017 - 2028)

  • Cancer

  • Immunology

  • Neurology

  • Stem cell

  • Non-invasive prenatal diagnosis

  • In-vitro fertilization

  • Others

• Workflow Outlook (Revenue, USD Million, 2017 - 2028)

  • Single Cell Isolation & Library Preparation

  • Downstream Analysis

  • Data Analysis

• End-use Outlook (Revenue, USD Million, 2017 - 2028)

  • Academic & Research Laboratories

  • Biotechnology and Pharmaceutical Companies

  • Hospitals and Diagnostic Laboratories

  • Others

• Regional Outlook (Revenue, USD Million, 2017 - 2028)

  • North America

    • U.S.

    • Canada

  • Europe

    • Germany

    • U.K.

    • France

    • Italy

    • Spain

  • Asia Pacific

    • China

    • India

    • Japan

    • South Korea

  • Latin America

    • Mexico

    • Brazil

  • MEA

    • South Africa

    • Saudi Arabia