GVR Report cover Nucleic Acid Isolation And Purification Market Size, Share & Trends Report

Nucleic Acid Isolation And Purification Market Size, Share & Trends Analysis Report By Product (Instruments, Kits & Reagents), By Type, By Application, By Method (Column-based, Magnetic Beads), By End-use, By Region, And Segment Forecasts, 2021 - 2028

  • Report ID: GVR-2-68038-580-9
  • Number of Pages: 175
  • Format: Electronic (PDF)
  • Historical Range: 2017 - 2019
  • Industry: Healthcare

Report Overview

The global nucleic acid isolation and purification market size was valued at USD 4.1 billion in 2020 and is expected to expand at a compound annual growth rate (CAGR) of 11.4% from 2021 to 2028. Key drivers contributing to the market growth are the rise in adoption of sequencing platforms in clinical diagnostics, growth in genomics and enzymology-based research, and increasing investments in R&D pertaining to molecular biology and precision medicine.

U.K. nucleic acid isolation & purification market size, by method, 2018 - 2028 (USD Million) 

The growing collaborations between different companies and organizations in the biotech industry is one of the factors driving the market. For instance, in March 2020, Zymo Research and Tecan partnered to introduce ready-to-use processing products that can streamline DNA or RNA extraction from COVID-19 specimens. The new DreamPrep NAP workstation assists laboratories to effectively and rapidly scale lab testing to provide a larger number of tests, consequently helping in mitigating the spread of the virus.      

The development of personalized medicine is another important factor that drives revenue generation in the market for nucleic acid isolation and purification. Next Generation Sequencing (NGS) is becoming increasingly popular in cancer tumor biopsies. Liquid biopsies are an attractive option for cancer diagnostics because the process employs a simple and routine test that can detect cancer at an early stage.

Early diagnosis of cancer is the biggest challenge, and NGS can help effectively tackle the problem, increasing the demand for NGS technology. Therefore, an increase in the use of NGS technology is anticipated to directly impact the adoption of nucleic acid isolation and purification techniques.

Formalin-Fixed Paraffin-Embedded (FFPE) samples that are considered important in determining molecular correlates of carcinogenesis require labor-intensive nucleic acid purification for the sample, and such protocols also damage the nucleic acids. To combat such challenges companies are launching new extraction kits for efficient recovery of nucleic acids.

For instance, in March 2021, Purigen Biosystems, Inc. launched the Ionic FFPE Complete Purification Kit for recovering RNA/DNA from FFPE tissue samples in a single workflow. It helps in streamlining the workflow by reducing hands-on time by around 75% when compared to the manual column or bead-based methods. Hence, such advancements are further boosting the market growth.

Furthermore, the COVID-19 pandemic is acting as a positive catalyst for the growth of the market for nucleic acid isolation and purification. Researchers and companies across the world are focusing on developing specific assays and kits for rapid detection of SARS-CoV-2. For instance, in June 2020, Omega Bio-tek, Inc. launched Mag-Bind Viral RNA Xpress Kit for efficient and rapid isolation of viral RNA. In addition, the company also announced to have a production capacity of 6 million tests per month which brought a dramatic increase in the production capacities.

Product Insights

The kits and reagents segment dominated the market for nucleic acid isolation and purification in 2020 and accounted for the largest revenue share of 76.0%. The wide-scale application of kits and reagents for DNA and RNA isolation for preparing samples and libraries can be primarily attributed to market growth. In addition, a rising number of research studies focused on understanding rare and common genome-based diseases are increasingly using kits and reagents, which is further driving the segment.

The instruments segment is expected to witness the fastest CAGR of 12.6% over the forecast period. The growth in the segment can be attributed to the launch of new instruments facilitating automation, rapid technological innovation, and growing demand for automated Nucleic Acid Isolation and Purification (NAIP) instruments.

For instance, in April 2020, Thermo Fisher Scientific, Inc. collaborated with Hamilton Company to develop an automated nucleic acid extraction platform for forensic laboratory purposes. The ID NIMBUS Presto assay facilitates automated DNA extraction from samples collected from the crime scene.

Type Insights

The RNA isolation and purification segment dominated the market for nucleic acid isolation and purification and accounted for the largest revenue share of 53.6% in 2020 owing to the increasing application in COVID-19 diagnostics and rise in use of purified mRNA for the construction of the cDNA library. These libraries have various applications such as gene expression profiling, sequencing, and clinical diagnostics. Moreover, the availability of a broad range of kits for extraction and processing of viral and bacterial RNA is further contributing to segment growth.

DNA isolation and purification is expected to witness lucrative growth of 13.5% during the forecast period owing to its increasing application in gene expression profiling. In addition, pharmaceutical and biotechnology companies are undertaking various strategic initiatives such as the launch of new products for efficiently carrying out nucleic acid isolation steps.

For instance, in February 2020, Promega Corporation launched its Wizard HMW DNA Extraction Kit. The kit helped researchers in working with large DNA fragments, facilitating steady performance during long-read sequencing applications.

Viral DNA extraction and purification is increasingly gaining attention for their therapeutic and diagnostic applications. For instance, they are used as vectors for gene therapy and nanobiological weapons for fighting other viruses. The utilization of viral DNA in the market is henceforth gaining momentum through the coming years.

Method Insights

The magnetic beads segment dominated the market for nucleic acid isolation and purification and accounted for the largest revenue share of 37.9% in 2020 and is expected to continue the trend in the coming years. The growing adoption of magnetic beads is owing to the advantage that it provides researchers and scientists with improved assay performance and better isolation and purification of DNA and RNA.

In recent years, functionalized magnetic beads have been used along with suitable buffer systems for rapid and efficient extraction. This method reduces the requirement of centrifugation that usually results in the breaking of nucleic acids. Hence, such a positive aspect of this technology provides automated extraction with minimal requirement of centrifugation for nucleic acid isolation steps.

Column-based techniques are expected to witness substantial CAGR through the forecast period. Silica columns are extensively preferred for obtaining higher quality nucleic acids in a short time. In addition, these techniques can be incorporated in microchips and spin columns that have several advantages such as cost-effectivity, fast organic extraction, and compatibility with automated instruments. Hence, such methods are widely adopted in nucleic acid isolation methods.

Application Insights

The diagnostics segment accounted for the largest revenue share of 34.3% in 2020. The large share of the segment can be attributed to the rising application of DNA and RNA isolation for the identification of pathogens in routine sample processing. For instance, PCR techniques are widely adopted for the rapid detection of microorganisms, which was previously not possible with traditional microbiological detection methods.

Moreover, companies are launching new diagnostic solutions for identifying emerging infections and diseases. For instance, in February 2021, ThermoFisher Scientific, Inc. launched Applied Biosystems TaqPath COVID–19 HT Kit to conduct COVID-19 diagnostic assay. This product is a high-throughput version of the company’s TaqPath COVID-19 CE-IVD RT-PCR Kit. Hence, the launch of new products for diagnosing various new emerging infections is further contributing to segment growth. 

The drug discovery and development segment is expected to witness a lucrative growth rate of 12.1% over the forecast period. Growth in the segment can be primarily attributed to robust investments in pharmaceutical and biotechnology companies for the development of novel drugs. Nucleic acid purification methods are largely employed in various steps of drug discovery, target identification, and testing.

End-use Insights

The hospitals and diagnostic centers segment dominated the market for nucleic acid isolation and purification and accounted for the largest revenue share of 33.6% in 2020 owing to increasing demand for early and accurate diagnosis of diseases. DNA/RNA isolation and purification techniques are considered efficient tools for the diagnosis of even genetic diseases such as sickle cell anemia, hemophilia A, and Tay-Sachs disease. Hence, the availability of such efficient technologies at moderate to low prices is expected to increase their adoption rate in diagnostic centers and hospitals.

Global nucleic acid isolation & purification market share, by end-use, 2020 (%)

Pharmaceutical and biotechnology companies are anticipated to witness the fastest growth rate of 11.8% during the forecast period. The rapid adoption of emerging technologies by companies for the development of various therapies is anticipated to fuel market growth. As nucleic acid isolation and purification is the initial step for manufacturing various drugs and therapies, it will certainly drive the adoption of instruments and kits associated with conducting these processes.

Regional Insights

North America dominated the market for nucleic acid isolation and purification and held the largest revenue share of 36.7% in 2020. The presence of established players and their efforts in developing technologically advanced rapid purification and isolation devices is the major contributor to market growth in the region. In addition, the rising funding initiatives for biotechnology research are further propelling the growth of the market in the region.

Asia Pacific is the fastest-growing region in the nucleic acid isolation and purification market. The factors contributing to the growth of the market in the region include rising economic growth, extensive research in life sciences, growing patient population, supportive government initiatives, and the presence of various innovative biotech companies in the region.

Key Companies & Market Share Insights

The market for nucleic acid isolation and purification is moderately fragmented with the presence of large well-established players. These players are undertaking several initiatives to expand their DNA or RNA extraction instruments and kits. For instance, in January 2020, QIAGEN stated that it has completed 2,500 placements of its QIAsymphony instrument. These placements represent a great milestone for QIAGEN’s magnetic bead-based instruments. QIAsymphony has the broadest test portfolio of any platform in its category in the European market. Some of the prominent players in the nucleic acid isolation and purification market include:


  • Thermo Fisher Scientific, Inc.

  • Illumina, Inc.  

  • Danaher

  • F. Hoffmann-La Roche AG

  • Merck KGaA

  • Agilent Technologies

  • Bio-Rad Laboratories, Inc.

  • Takara Bio, Inc.

  • Promega Corporation

  • New England Biolabs

  • LGC Limited

  • Abcam plc

  • Norgen Biotek Corp

  • AutoGen, Inc.

  • Biogenuix

  • PCR Biosystems, Inc.

  • MagGenome

  • Apical Scientific Sdn. Bhd


Nucleic Acid Isolation And Purification Market Report Scope

Report Attribute


Market size value in 2021

USD 4.6 billion

Revenue forecast in 2028

USD 9.8 billion

Growth rate

CAGR of 11.4% from 2021 to 2028

Base year for estimation


Historical data

2017 - 2019

Forecast period

2021 - 2028

Quantitative units

Revenue in USD million and CAGR from 2021 to 2028

Report coverage

Revenue forecast, company ranking, competitive landscape, growth factors, and trends

Segments covered

Product, type, method, application, end-use, region

Regional scope

North America; Europe; Asia Pacific; Latin America; Middle East & Africa

Country scope

U.S.; Canada; Germany; U.K.; China; Japan, Brazil; Mexico, South Africa

Key companies profiled

QIAGEN; Thermo Fisher Scientific, Inc.; Illumina, Inc.; Danaher; F. Hoffmann-La Roche AG; Merck KGaA; Agilent Technologies; Bio-Rad Laboratories, Inc.; Takara Bio, Inc.; Promega Corporation; New England Biolabs; LGC Limited; Abcam plc; Norgen Biotek Corp; AutoGen, Inc.; Biogenuix; PCR Biosystems, Inc.; MagGenome; Apical Scientific Sdn. Bhd; MACHEREY-NAGEL GmbH & Co. KG

Customization scope

Free report customization (equivalent to up to 8 analysts working days) with purchase. Addition or alteration to country, regional & segment scope.

Pricing and purchase options

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Segments Covered in the Report

This report forecasts revenue growth at global, regional, and country levels and provides an analysis of the latest industry trends in each of the sub-segments from 2017 to 2028. For the purpose of this study, Grand View Research has segmented the global nucleic acid isolation and purification market report on the basis of product, type, method, application, end-use, and region:

  • Product Outlook (Revenue, USD Million, 2017 - 2028)

    • Kits & Reagents

    • Instruments

  • Type Outlook (Revenue, USD Million, 2017 - 2028)

    • DNA Isolation & Purification

      • Genomic DNA Isolation & Purification

      • Plasmid DNA Isolation & Purification

      • Viral DNA Isolation & Purification

      • Other

    • RNA Isolation & Purification

      • miRNA Isolation & Purification

      • mRNA Isolation & Purification

      • Total RNA Isolation & Purification

      • Other

  • Method Outlook (Revenue, USD Million, 2017 - 2028)

    • Column-based

    • Magnetic Beads

    • Reagent-based

    • Others

  • Application Outlook (Revenue, USD Million, 2017 - 2028)

    • Precision Medicine

    • Diagnostics

    • Drug Discovery & Development

    • Agriculture and Animal Research

    • Other Applications

  • End-use Outlook (Revenue, USD Million, 2017 - 2028)

    • Academic Research Institutes

    • Pharmaceutical & Biotechnology Companies

    • Contract Research Organizations

    • Hospitals and Diagnostic Centers

    • Other End-use

  • Regional Outlook (Revenue, USD Million, 2017 - 2028)

    • North America

      • U.S.

      • Canada

    • Europe

      • Germany

      • U.K.

    • Asia Pacific

      • China

      • Japan

    • Latin America

      • Brazil

      • Mexico

    • Middle East and Africa (MEA)

      • South Africa

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